Symmetry breaking organizes the brain's resting state manifold - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Cold Spring Harbor Laboratory Press Année : 2023

Symmetry breaking organizes the brain's resting state manifold

Résumé

Spontaneously fluctuating brain activity patterns that emerge at rest have been linked to brain's health and cognition. Despite detailed descriptions of the spatio-temporal brain patterns, our understanding of their generative mechanism is still incomplete. Using a combination of computational modeling and dynamical systems analysis we provide a mechanistic description of the formation of a resting state manifold via the network connectivity. We demonstrate that the symmetry breaking by the connectivity creates a characteristic flow on the manifold, which produces the major data features across scales and imaging modalities. These include spontaneous high amplitude co-activations, neuronal cascades, spectral cortical gradients, multistability and characteristic functional connectivity dynamics. When aggregated across cortical hierarchies, these match the profiles from empirical data. The understanding of the brain's resting state manifold is fundamental for the construction of task-specific flows and manifolds used in theories of brain function such as predictive coding. In addition, it shifts the focus from the single recordings towards brain's capacity to generate certain dynamics characteristic of health and pathology.

Domaines

Neurosciences
Fichier principal
Vignette du fichier
2022.01.03.474841v2.full.pdf (2.34 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04086340 , version 1 (02-05-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Jan Fousek, Giovanni Rabuffo, Kashyap Gudibanda, Hiba Sheheitli, Viktor Jirsa, et al.. Symmetry breaking organizes the brain's resting state manifold. Cold Spring Harbor Laboratory Press, 2023, ⟨10.1101/2022.01.03.474841⟩. ⟨hal-04086340⟩
83 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More