DNA methylation in Schwann cells and in oligodendrocytes - Aix-Marseille Université
Article Dans Une Revue (Article De Synthèse) Glia Année : 2022

DNA methylation in Schwann cells and in oligodendrocytes

Résumé

DNA methylation is one of many epigenetic marks, which directly modifies base residues, usually cytosines, in a multiple-step cycle. It has been linked to the regulation of gene expression and alternative splicing in several cell types, including during cell lineage specification and differentiation processes. DNA methylation changes have also been observed during aging, and aberrant methylation patterns have been reported in several neurological diseases. We here review the role of DNA methylation in Schwann cells and oligodendrocytes, the myelin-forming glia of the peripheral and central nervous systems, respectively. We first address how methylation and demethylation are regulating myelinating cells' differentiation during development and repair. We then mention how DNA methylation dysregulation in diseases and cancers could explain their pathogenesis by directly influencing myelinating cells' proliferation and differentiation capacities.
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Dates et versions

hal-04146375 , version 1 (30-06-2023)

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Peter Arthur-Farraj, Sarah Moyon. DNA methylation in Schwann cells and in oligodendrocytes. Glia, 2022, 14 (8), pp.1568-1583. ⟨10.1002/glia.23784⟩. ⟨hal-04146375⟩

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