Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues

Highlights d An RNAPII atlas of intergenic transcription in normal tissues and cancer samples d Intergenic atlas shows enhancer-like characteristics and transcriptional signals d Meta-clustering reveals shared transcriptional patterns among tissues and cancer types d Identified intergenic markers associated with cancer genes and survival

Keywords

enhancers non-coding DNA regulatory genomics intergenic RNA Polymerase II gene regulation cancer genomics non-coding transcription

Domains

Genomics [q-bio.GN]

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mmc7.pdf (21.93 Mo)

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Lionel Spinelli : Connect in order to contact the contributor

https://amu.hal.science/hal-04228229

Submitted on : Wednesday, October 4, 2023-12:53:22 PM

Last modification on : Thursday, February 1, 2024-2:20:47 PM

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hal-04228229 , version 1 (04-10-2023)

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HAL Id : hal-04228229 , version 1
DOI : 10.1016/j.xgen.2023.100411

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Pierre de Langen, Fayrouz Hammal, Elise Guéret, Jean-Christophe Mouren, Lionel Spinelli, et al.. Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues. Cell Genomics, 2023, 3, pp.100411. ⟨10.1016/j.xgen.2023.100411⟩. ⟨hal-04228229⟩

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