Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases - Aix-Marseille Université Access content directly
Journal Articles Cell Biochemistry and Biophysics Year : 2017

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases

Abstract

NADPH oxidases are a family of enzymes capable of transferring electrons from NADPH to molecular oxygen. A major function of NADPH oxidases is the activation of molecular oxygen into reactive oxygen species. Increased activity of NADPH oxidases has been implicated in various pathologies, including cardiovascular disease, neurological dysfunction, and cancer. Thus, NADPH oxidases have been identified as a viable target for the development of novel therapeutics exhibiting inhibitory effects on NADPH oxidases. Here, we describe the development of new assays for measuring the activity of NADPH oxidases enabling the high-throughput screening for NADPH oxidase inhibitors.

Dates and versions

hal-01774183 , version 1 (23-04-2018)

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Jacek Zielonka, Micael Hardy, Radoslaw Michalski, Adam Sikora, Monika Zielonka, et al.. Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. Cell Biochemistry and Biophysics, 2017, 75 (3-4), pp.335--349. ⟨10.1007/s12013-017-0813-6⟩. ⟨hal-01774183⟩
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