2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one - Aix-Marseille Université Access content directly
Journal Articles Molbank Year : 2021


Romain Mustière
  • Function : Author
  • PersonId : 1100729
Patrice Vanelle
  • Function : Author
  • PersonId : 973296
Nicolas Primas
  • Function : Author
  • PersonId : 996149


As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described
Fichier principal
Vignette du fichier
2021 Mustiere Molbank 2021 2 M1221.pdf (1.14 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03246463 , version 1 (02-06-2021)





Romain Mustière, Patrice Vanelle, Nicolas Primas. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank, 2021, 2021 (2), ⟨10.3390/m1221⟩. ⟨hal-03246463⟩
56 View
77 Download



Gmail Facebook X LinkedIn More