2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one - Aix-Marseille Université Access content directly
Journal Articles Molbank Year : 2021

2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one

Romain Mustière
  • Function : Author
  • PersonId : 1100729
Patrice Vanelle
  • Function : Author
  • PersonId : 973296
Nicolas Primas
  • Function : Author
  • PersonId : 996149

Abstract

As part of our ongoing scaffold hopping work on antimalarial 2-aminothieno[3,2-d]pyrimidin-4-one scaffold, we explored the dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one as a potential new antimalarial series. Using conditions found in the literature, we obtained 2-cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one with 93% yield through a simple treatment. It was then characterized by NMR (1H and 13C) and HRMS. Given the structure of this molecule, its aqueous stability was assessed to determine its suitability for biological tests. To our knowledge, this is the first dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one described
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hal-03246463 , version 1 (02-06-2021)

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Romain Mustière, Patrice Vanelle, Nicolas Primas. 2-Cyclopropyl-6-phenyl-2,3-dihydrothieno[3,2-d][1,3,2]diazaborinin-4(1H)-one. Molbank, 2021, 2021 (2), ⟨10.3390/m1221⟩. ⟨hal-03246463⟩
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